Dietary Fiber and Giardiasis: Dietary Fiber Reduces Rate of Intestinal Infection by Giardia Lamblia in the Gerbil
danach "Giardiasis: pathophysiology and management": PDF, HTML.
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Dietary Fiber
Dietary fiber may play an important role in the clearance of Giardia infection. Utilizing animal models, Leitch et al demonstrated consumption of a diet high in insoluble fiber significantly protects against Giardia infection. Animals consuming a low-fiber diet were significantly more likely to contract giardiasis when inoculated with Giardia cysts than animals on a high-fiber diet (p [less than or equal to] 0.05). When infected animals on the low-fiber diet were put on the high-fiber diet, trophozoites were cleared from the small bowel. The number of trophozoites attached to the jejunal epithelium decreased, while the number associated with the mucus layer increased. The authors concluded that the fiber induced an increase in mucus secretion and, in combination with the bulk movement of insoluble fiber, reduced trophozoite attachment to the intestinal mucosa and decreased the probability of trophozoites establishing and maintaining mucosal colonization. (28)
Insoluble fiber intake has been demonstrated to markedly increase the relative number of goblet cells along the GI tract and significantly enhance luminal mucin levels in the small bowel. (27) This may partly explain how fiber can prevent and treat Giardia infections. Insoluble fiber may also "sweep" out Giardia trophozoites, as suggested above by Leitch et al.
When ingested, both soluble fibers (49) and lignins (50) have the capacity to bind to bile salts. This may effectively reduce the quantity of bile salts available to Giardia trophozoites, which depend on these salts for continued growth and survival. Hence, consumption of foods high in insoluble and soluble fibers, as well as lignins, may play a significant role in aiding Giardia clearance via multiple mechanisms.
Statistik: Verfasst von Johnny99 — 09.05.2010, 10:20
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